Searchable abstracts of presentations at key conferences in endocrinology

ea0029s14.1 | Wnt/Beta-catenin in pituitary development and disease | ICEECE2012

β-catenin deficiency disrupts patterning of the ventral diencephalon, causing adenohypophysis over growth and dysmorphology

Camper S. , Mortensen A. , Davis S.

β-catenin is thought to play an important, intrinsic role in early pituitary development by regulating adenohypophysis (anterior pituitary) transcription factor activity. Expression of β-catenin is detected in the adenohypophysis, rostral mesenchyme, and neural ectoderm, including the area that develops into the infundibulum and neurohypophysis, and nearby regions. The importance of β-catenin expression in the neural ectoderm and mesenchyme has not been addresse...